• Lawrence R Robinson, Joseph M Czerniecki, Dawn M Ehde, W Thomas Edwards, David A Judish, Myron L Goldberg, Kellye M Campbell, Douglas G Smith, and Mark P Jensen.
• Department of Rehabilitation Medicine, University of Washington, Seattle 98104, USA. lorenzo@u.washington.edu
• Arch Phys Med Rehabil. 2004 Jan 1;85(1):1-6.

ObjectiveTo evaluate whether amitriptyline is more effective than placebo in improving phantom limb pain or residual limb pain.DesignRandomized controlled trial of amitriptyline for 6 weeks.SettingUniversity hospital.ParticipantsThirty-nine persons with amputation-related pain lasting more than 6 months.InterventionSix-week trial of amitriptyline (titrated up to 125 mg/d) or an active placebo (benztropine mesylate).Main Outcome MeasuresAnalyses were conducted to examine whether there was a medication group effect on the primary outcomes (average pain intensity) and secondary outcome measures (disability, satisfaction with life, handicap).ResultsNo significant differences were found between the treatment groups in outcome variables when controlling for initial pain scores.ConclusionsOur findings do not support the use of amitriptyline in the treatment of postamputation pain.

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