• Ann. Clin. Biochem. · Jul 2014

    Measurement of plasma viscosity by free oscillation rheometry: imprecision, sample stability and establishment of a new reference range.

    • Lise Pedersen, Erling B Nielsen, Majbrit K Christensen, Maybritt Buchwald, and Mads Nybo.
    • Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark lise-pedersen@rsyd.dk.
    • Ann. Clin. Biochem. 2014 Jul 1;51(Pt 4):495-8.

    BackgroundPlasma viscosity (PV) is used in the investigation of hyperviscosity syndrome. We have evaluated the performance of a new bench-top free oscillation rheometer, ReoRox from Medirox, and established a new reference range.MethodsPerformance of the free oscillation rheometry (FOR) method was evaluated examining within-run and between-run imprecision, duration of measurement and operator simplicity. Furthermore, influence of storage on the PV measurements was assessed and a reference range based on plasma from 585 healthy men and women was established.ResultsImprecision of the free oscillation rheometer was comparable to other viscometers and performance of the instrument was satisfying. The non-parametrical reference range established was 1.22-1.44 mPa s at 37℃ (2.5th and 97.5th percentiles).ConclusionsWe have established a FOR PV reference range to support clinical decision-making. Furthermore, we found high pre-analytical stability of the samples and an analytical imprecision comparable to other PV methods.© The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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