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Comparative Study
Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass.
- K Svennevig, Tn Hoel, As Thiara, So Kolset, A Castelheim, Te Mollnes, F Brosstad, E Fosse, and Jl Svennevig.
- Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway. katja.svennevig@medisin.uio.no
- Perfusion. 2008 May 1;23(3):165-71.
AbstractThe glycocalyx covering the endothelium is shed during ischemia and reperfusion. The shedding is accompanied by increased levels of the glycocalyx component syndecan-1 in the circulation. Our aim was to compare plasma levels of syndecan-1 in patients undergoing coronary artery bypass grafting (CABG), with or without the use of cardiopulmonary bypass (CPB). Syndecan-1 plasma concentrations were measured in patients undergoing CABG on-pump (nA =A 22) or off-pump (nA =A 22). The syndecan-1 concentration increased significantly from 29.5 +/- 4.6 ng/mL at baseline to 98.7 +/- 9.8 ng/mL (pA
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