• Langenbecks Arch Surg · May 2008

    Procalcitonin in preoperative diagnosis of abdominal sepsis.

    • Nenad Ivancević, Dejan Radenković, Vesna Bumbasirević, Aleksandar Karamarković, Vasilije Jeremić, Nevena Kalezić, Tatjana Vodnik, Biljana Beleslin, Natasa Milić, Pavle Gregorić, and Milos Zarković.
    • Center of Emergency Surgery, Clinical Centre of Serbia, Belgrade, Serbia. mivancevic@sbb.co.yu
    • Langenbecks Arch Surg. 2008 May 1;393(3):397-403.

    Background And AimsThe present study attempted to identify the diagnostic significance of procalcitonin (PCT) in acute abdominal conditions as well as the range of concentrations relating to diagnosis of abdominal sepsis.Materials And MethodsThis was prospective clinical study. The study included 98 consecutive patients with acute abdominal conditions, divided in sepsis and systemic inflammatory response syndrome (SIRS) group.ResultsPCT concentrations on admission were significantly higher in the sepsis group than in the SIRS group (median [interquartile range] 2.32 [7.41] vs 0.45 ng/ml [2.62]). A cutoff value of 1.1 ng/ml yielded 72.4% sensitivity and 62.5% specificity. In a group of patients with abdominal symptoms lasting for more than 24 h, a cut-off value of 1.1 ng/ml yielded higher sensitivity (82.9%) and higher specificity (77.3%).ConclusionOur results suggest that PCT measurements may be useful for early, preoperative diagnosis of abdominal sepsis.

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