• Neuroreport · Sep 2004

    Comparative Study

    Stimulation of PAR-2 excites and sensitizes rat cutaneous C-nociceptors to heat.

    • Danping Ding-Pfennigdorff, Beate Averbeck, and Martin Michaelis.
    • Aventis Pharma Deutschland GmbH, DG Thrombosis and Degenerative Joint Diseases, Industriepark Hoechst, D-65929 Frankfurt, Germany.
    • Neuroreport. 2004 Sep 15;15(13):2071-5.

    AbstractProteinase-activated receptor 2 (PAR-2) is expressed on many nociceptive neurons. Application of PAR-2 agonists has been shown to induce behavioral signs of hyperalgesia. We investigated effects of the rat PAR-2 agonist SLIGRL-NH2 in the isolated rat skin-saphenous nerve preparation. SLIGRL-NH2 (100 microM) excited 20% of all C-fiber nociceptors tested. In addition, C-fiber nociceptors were sensitized to heat after SLIGRL-NH2 application resulting in an increase in response magnitude and a decrease of heat threshold. The PAR-2-inactive control peptide LRGILS-NH2 had no effect. The mechanical sensitivity of C-fibers was not affected by SLIGRL-NH2. PAR-2-mediated excitation and sensitization of primary nociceptors may contribute to PAR-2-mediated hyperalgesia.

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