• Anesthesiology · May 1975

    Comparative Study Clinical Trial Controlled Clinical Trial

    Relative analgesic potencies of morphine and hydromorphone in postoperative pain.

    • D L Mahler and W H Forrest.
    • Anesthesiology. 1975 May 1;42(5):602-7.

    AbstractBecause of discrepancies in the estimates of the relative analgesic potencies of hydromorphone and morphine, the drugs were compared in two four-point, double-blind bioassays. In the first study, hydromorphone, 1 and 2 mg, was compared with morphine, 5 and 10 mg, in 31 postoperative patients; in the second, hydromorphone, 0.5 and 1 mg, was compared with morphine, 5 and 10 mg, in 112 postoperative patients. Subjective responses to nurse-observer questions were used to quantitate analgesia for postoperative pain. Hydromorphone is more potent than commonly believed: approximately 0.9 to 1.2 mg is equianalgesic with 10 mg of morphine, with a similar incidence of side effects.

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