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Randomized Controlled Trial Comparative Study
Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty.
- Mohammad Mahdi Sarzaeem, Mohammad Razi, Gholamhosein Kazemian, Mohammad Emami Moghaddam, Alireza Manafi Rasi, and Meysam Karimi.
- Department of Orthopedics, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- J Arthroplasty. 2014 Aug 1;29(8):1521-4.
AbstractThe ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four groups. In group 1,500 mg TXA was administered intravenously. In group 2, the joint irrigated with 3 g of TXA in 100 cc of saline. In group 3, 1.5 g of TXA was injected through the drain. Group 4 did not take TXA. Albeit all methods had a statistical effect on hemoglobin drop, drainage and number of transfused units when compared to controls, but intravenous injection of TXA seems to be much more effective in terms of reducing hemoglobin drop and transfused units; and what's more TXA injection by drain is more effective regarding to reducing postoperative drainage.Copyright © 2014 Elsevier Inc. All rights reserved.
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