• Pharmacol. Ther. · Jan 2013

    Review

    New targets and approaches in osteosarcoma.

    • Jonathan Gill, Manpreet K Ahluwalia, David Geller, and Richard Gorlick.
    • Department of Pediatrics, Montefiore Medical Center and The Children's Hospital at Montefiore, Bronx, NY, United States.
    • Pharmacol. Ther. 2013 Jan 1;137(1):89-99.

    AbstractOsteosarcoma is the most common primary tumor of bone. Approximately 2/3 of patients who present with localized osteosarcoma can be expected to be cured of their disease with surgery and routine chemotherapy. Only 1/3 of patients with metastases detectable at presentation will be cured. These survival trends have stagnated over the past 20 years using conventional chemotherapy. New agents need to be rationally investigated to strive for improvement in the survival of patients diagnosed with osteosarcoma. This manuscript will review the rationale for conventional chemotherapy used in the treatment of osteosarcoma, as well as agents in varying stages of development that may have promise for treatment in the future.Copyright © 2012 Elsevier Inc. All rights reserved.

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