• Br J Anaesth · Apr 1988

    Randomized Controlled Trial Comparative Study Clinical Trial

    Adrenocortical hormone concentrations in children during cardiopulmonary bypass with and without pulsatile flow.

    • E M Pollock, J C Pollock, M P Jamieson, G S Beastall, C Wright, B Torsney, and L R McNicol.
    • (Department of Anaesthesia), Royal Hospital for Sick Children, Yorkhill, Glasgow.
    • Br J Anaesth. 1988 Apr 1;60(5):536-41.

    AbstractPlasma cortisol and ACTH concentrations were measured in two groups of children (aged 1-16 yr). Ten children underwent routine (non-pulsatile) cardiopulmonary bypass and 10 underwent pulsatile bypass under moderate hypothermia (28-32 degrees C). Comparable increases in cortisol and ACTH concentrations were demonstrated at the onset of bypass and the concentrations of both hormones increased during bypass. In the post-bypass period plasma cortisol concentration increased sharply; there was no further increase in the plasma ACTH concentration. By 24 h the concentrations of both hormones had declined towards baseline values. There were no significant differences between the groups.

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