• Anesthesiology · Aug 1983

    A new approach to differential peripheral nerve fiber block: Na+,K+-ATPase inhibition.

    • B R Fink and A M Cairns.
    • Anesthesiology. 1983 Aug 1;59(2):127-31.

    AbstractDifferential block of peripheral nerve fibers was attempted in vitro by a new approach based on inhibiting the membrane pump with ouabain. Sequential concentration dependent extinction of the components of the compound action potential was obtained: C extinguished first, A delta next, A beta last. The sequence conforms to expectations based on axonal size. Because pain is mediated by C and A delta fibers, and block of these groups by ouabain was not reversed readily, further investigation of the practicability of the new approach seems warranted.

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