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Int. J. Gynecol. Cancer · Feb 2010
Case ReportsSubcutaneous methylnaltrexone to restore postoperative bowel function in a long-term opiate user.
- Andras Ladanyi, Sarah M Temkin, and Jonathan Moss.
- Department of Obstetrics and Gynecology, The University of Chicago, Chicago, IL, USA.
- Int. J. Gynecol. Cancer. 2010 Feb 1;20(2):308-10.
IntroductionOne of the most common undesired effects of analgesic opioid use and addiction is constipation. Numerous pharmacologic agents have been used to treat opioid-induced bowel hypomotility with limited success. Methylnaltrexone bromide (MNTX) selectively targets the peripheral adverse effects of opioids while preserving the central analgesic effects of opioid agonist treatment.CaseWhile it is indicated for use in nonsurgical patients in the palliative care setting, here we report the use of MNTX for the alleviation of postoperative ileus in a heroin user with recurrent cervical cancer undergoing diverting colostomy and urinary conduit placement.ConclusionsResults suggest that MNTX may accelerate postoperative gastrointestinal recovery in opioid-dependent patients. Further studies are warranted to evaluate its role in the pharmacologic management of postoperative ileus.
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