• Jean-Louis Vincent.
• a Department of Intensive Care , Erasme Hospital, Université libre de Bruxelles , Brussels , Belgium.
• Expert Opin Drug Saf. 2016 Jan 1; 15 (2): 215-21.

IntroductionThe management of sepsis essentially relies on effective resuscitation with fluids and vasopressors, appropriate and adequate antimicrobial therapy, and organ support. Any of these interventions can have beneficial but also harmful effects.Areas CoveredWe focus on the key hemodynamic signs of sepsis and discuss the potential safety risks associated with the management of each of them, including optimizing arterial pressure, cardiac output and oxygen delivery. We also underline the importance of the timing of interventions.Expert OpinionPatients with septic shock are heterogeneous, making it particularly difficult to provide therapeutic recommendations that are safe and effective for all. A personalized medicine approach should be used with treatment decisions carefully considered and the risks and benefits of each intervention balanced in each individual patient.

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