• Endocr Pract · Nov 2012

    Review Case Reports

    Danger of hypoglycemia due to acute tramadol poisoning.

    • Nadarajah Mugunthan and Peter Davoren.
    • Department of Endocrinology and General Medicine, Gold Coast Hospital, Southport, Queensland, Australia. mugunthan66@hotmail.com
    • Endocr Pract. 2012 Nov 1;18(6):e151-2.

    ObjectiveTo report a case of prolonged hypoglycemia after acute tramadol poisoning.MethodsWe describe a patient's clinical presentation and outcome with prolonged hypoglycemia attributable to acute tramadol poisoning. In addition, the possible mechanism for the hypoglycemia is discussed, and a brief review of the pertinent literature is presented.ResultsA 54-year-old woman had previously undergone a partial hepatectomy because of involvement of her liver by a gastrointestinal stromal tumor. After ingestion of 3,000 mg of tramadol with suicidal intent, she developed prolonged hypoglycemia that necessitated treatment with continuous intravenous glucose infusion for 24 hours. Reports in the literature have described central nervous system depression, nausea, vomiting, tachycardia, seizures, and even death from tramadol overdoses.ConclusionThis report alerts clinicians to the potential danger of severe hypoglycemia in tramadol poisoning.

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