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Randomized Controlled Trial Comparative Study Clinical Trial
Prophylaxis of heterotopic ossification after total hip arthroplasty: a prospective randomized study comparing indomethacin and meloxicam.
- Thomas Barthel, Bernd Baumann, Ulrich Nöth, and Jochen Eulert.
- Department of Orthopaedic Surgery, König-Ludwig-Haus, Julius Maximilians University, DE-97074 Würzburg, Germany. t-barthel.klh@mail.uni-wuerzburg.de
- Acta Orthop Scand. 2002 Dec 1;73(6):611-4.
AbstractWe performed a randomized, prospective study on the prophylaxis of heterotopic ossification (HO) after total hip arthroplasty (THR), comparing indomethacin and the selective COX-2 inhibitor meloxicam. From the day after surgery, 272 patients were treated with 7.5 mg meloxicam, 15 mg meloxicam, or 2 x 50 mg indomethacin a day, for 14 days. After 6 months, radiographs of patients treated with 7.5 mg meloxicam showed that HO had occurred in one third. This treatment was therefore stopped after 26 patients have been assigned to this group. According to the intention-to-treat principle, patients given 15 mg meloxicam developed HO in 25% (20% Brooker grade I, 4% grade II and 1% grade III) and those given indomethacin in 10% (7% Brooker grade I, 1% grade II and 2% grade III), a statistically significant difference.
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