• Eur. J. Pharmacol. · Dec 1993

    Effect of NG-nitro-L-arginine on shock induced by endotoxin and by platelet activating factor in dogs.

    • K Takekoshi, K Kasai, Y Suzuki, Y Sekiguchi, N Banba, T Nakamura, and S Shimoda.
    • Department of Endocrinology, Dokkyo University School of Medicine, Tochigi, Japan.
    • Eur. J. Pharmacol. 1993 Dec 21;250(3):465-7.

    AbstractWhen NG-nitro-L-arginine, a nitric oxide synthase inhibitor, administration was started 5 min prior to shock induction in anesthetized dogs, a partial restoration was observed in endotoxin-induced shock and a complete recovery in platelet activating factor (PAF)-induced shock. When NG-nitro-L-arginine infusion was started 5 min after shock induction, no significant recovery was observed in endotoxin-induced shock and a complete recovery in PAF-induced shock. These data indicate that enhanced production of nitric oxide by vascular endothelial cells may contribute to endotoxin- or PAF-induced shock and also that some mediators including inducible nitric oxide synthase and/or cellular damage might be involved in endotoxin-induced shock.

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