Biology and principles of scar management and burn

Surg. Clin. North Am. · Aug 2014

Review

Biology and principles of scar management and burn reconstruction.

Hypertrophic scarring is extremely common and is the source of most morbidity related to burns. The biology of hypertrophic healing is complex and poorly understood. Multiple host and injury factors contribute, but protracted healing of partial thickness injury is a common theme. ⋯ All have limited efficacy. Laser interventions for scar modification show promise, but as yet do not provide a definitive solution. Their efficacy is only seen when used as part of a multimodality scar management program.

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- Edward E Tredget, Benjamin Levi, and Matthias B Donelan.
- University of Edmonton, Edmonton, Alberta, Canada. Electronic address: etredget@ualberta.ca.
- Surg. Clin. North Am. 2014 Aug 1;94(4):793-815.
AbstractHypertrophic scarring is extremely common and is the source of most morbidity related to burns. The biology of hypertrophic healing is complex and poorly understood. Multiple host and injury factors contribute, but protracted healing of partial thickness injury is a common theme. Hypertrophic scarring and heterotopic ossification may share some basic causes involving marrow-derived cells. Several traditional clinical interventions exist to modify hypertrophic scar. All have limited efficacy. Laser interventions for scar modification show promise, but as yet do not provide a definitive solution. Their efficacy is only seen when used as part of a multimodality scar management program.Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.

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Biology and principles of scar management and burn reconstruction.

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