• Z Rheumatol · Mar 2014

    Case Reports

    [DRESS syndrome following sulfasalazine treatment].

    • M Pirklbauer and J Gruber.
    • Univ.Klinik für Innere Medizin VI, Medizinische Universität Innsbruck, Anichstr. 35, 6020, Innsbruck, Österreich.
    • Z Rheumatol. 2014 Mar 1;73(2):180-3.

    AbstractA female patient developed systemic rash, lung edema, electrocardiogram (ECG) abnormalities and fulminant hepatitis with partial liver failure 4 weeks after the start of sulfasalazine treatment. Peripheral T-cell activation, a positive PCR test for human herpesvirus (HHV) 6 as well as eosinophilia in bronchial lavage and a differential blood count were also present. After initiation of systemic corticosteroid therapy and cessation of accompanying medication the clinical symptoms and abnormal laboratory test levels were gradually resolved. A DRESS syndrome (drug rash with eosinophilia and systemic symptoms) was confirmed in accordance with the diagnostic criteria.

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