• Ragini Verma, Evangelia I Zacharaki, Yangming Ou, Hongmin Cai, Sanjeev Chawla, Seung-Koo Lee, Elias R Melhem, Ronald Wolf, and Christos Davatzikos.
• Department of Radiology, University of Pennsylvania, 3600 Market Street, Suite 380, Philadelphia, PA 19104, USA.
• Acad Radiol. 2008 Aug 1;15(8):966-77.

Rationale And ObjectivesTreatment of brain neoplasms can greatly benefit from better delineation of bulk neoplasm boundary and the extent and degree of more subtle neoplastic infiltration. Magnetic resonance imaging (MRI) is the primary imaging modality for evaluation before and after therapy, typically combining conventional sequences with more advanced techniques such as perfusion-weighted imaging and diffusion tensor imaging (DTI). The purpose of this study is to quantify the multiparametric imaging profile of neoplasms by integrating structural MRI and DTI via statistical image analysis methods to potentially capture complex and subtle tissue characteristics that are not obvious from any individual image or parameter.Materials And MethodsFive structural MRI sequences, namely, B0, diffusion-weighted images, fluid-attenuated inversion recovery, T1-weighted, and gadolinium-enhanced T1-weighted, and two scalar maps computed from DTI (ie, fractional anisotropy and apparent diffusion coefficient) are used to create an intensity-based tissue profile. This is incorporated into a nonlinear pattern classification technique to create a multiparametric probabilistic tissue characterization, which is applied to data from 14 patients with newly diagnosed primary high-grade neoplasms who have not received any therapy before imaging.ResultsPreliminary results demonstrate that this multiparametric tissue characterization helps to better differentiate among neoplasm, edema, and healthy tissue, and to identify tissue that is likely to progress to neoplasm in the future. This has been validated on expert assessed tissue.ConclusionThis approach has potential applications in treatment, aiding computer-assisted surgery by determining the spatial distributions of healthy and neoplastic tissue, as well as in identifying tissue that is relatively more prone to tumor recurrence.

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