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Nephrol. Dial. Transplant. · Jul 2010
Case ReportsAcute renal failure and Fanconi syndrome due to deferasirox.
- Steven Grangé, Dominique M Bertrand, Dominique Guerrot, Florence Eas, and Michel Godin.
- Nephrology Department, Rouen University Hospital, 1 Avenue de Germont, 76031 Rouen Cedex, Rouen, France. stevengrange@gmail.com
- Nephrol. Dial. Transplant. 2010 Jul 1;25(7):2376-8.
AbstractDeferasirox is the first oral iron chelator and, as such, is widely used for the treatment of chronic iron overload. However, recent data from large studies confirmed the renal toxicity of deferasirox. We report a case of Fanconi syndrome associated with acute renal failure in a patient receiving deferasirox. In particular, new insights regarding the pathophysiology of the renal disease due to this treatment are discussed. This case highlights the importance of a careful monitoring of kidney function, markers of proximal tubulopathy and ferritinaemia in patients receiving deferasirox.
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