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Antimicrob. Agents Chemother. · Jul 2011
Effect of moxifloxacin combined with cefotaxime compared to cefotaxime-gentamicin combination on prevention of white matter damage associated with Escherichia coli sepsis in neonatal rats.
- Nolwenn Le Saché, Olivier Baud, Julien Pansiot, Hoa Pham, Valérie Biran, Nadège Brunel-Meunier, Philippe Bidet, Marie-Dominique Kitzis, Pierre Gressens, Edouard Bingen, Christiane Charriaut-Marlangue, and Stéphane Bonacorsi.
- Université Paris Diderot, Equipe d'Accueil EA 3105, F-75019 Paris, France.
- Antimicrob. Agents Chemother. 2011 Jul 1;55(7):3567-9.
AbstractRelative to the cefotaxime-gentamicin combination, the moxifloxacin-cefotaxime combination significantly reduced microglial activation and immature oligodendrocyte cell death and delayed myelination in the developing white matter of neonatal rats with experimental Escherichia coli sepsis. These neuroprotective effects were not due to differences in in vivo bactericidal activities or in the systemic inflammatory responses and could be related to the intrinsic immunomodulatory properties of moxifloxacin. Molecular mechanisms underlying the neuroprotective effect of moxifloxacin remain to be elucidated.
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