• Jeffrey A Clark, Daqing Ma, H Mayumi Homi, Mervyn Maze, and Hilary P Grocott.
• Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
• J. Cardiothorac. Vasc. Anesth. 2005 Aug 1;19(4):488-93.

ObjectiveThe purpose of this study was to investigate the effect of xenon on the inflammatory response to cardiopulmonary bypass.DesignProspective, randomized experimental study.SettingUniversity research laboratory.ParticipantsSprague-Dawley rats.InterventionsAfter surgical preparation, rats were randomly divided into 4 groups: (1) SHAM rats were cannulated but did not undergo cardiopulmonary bypass; (2) cardiopulmonary bypass rats were subjected to 60 minutes of cardiopulmonary bypass using an oxygenator receiving a 30% O(2), 65% N(2), and 5% CO(2) gas mixture; (3) MK801 rats received MK801 (0.15 mg/kg intravenous) 15 minutes before 60 minutes of cardiopulmonary bypass with the same gas mixture; and (4) xenon rats underwent 60 minutes of cardiopulmonary bypass receiving a 30% O(2), 60% xenon, 5% N(2), and 5% CO(2) gas mixture.Measurements And Main ResultsAll bypass groups showed elevations in both cytokines compared with the SHAM-operated group. However, the inflammatory response to cardiopulmonary bypass in the group receiving xenon was no different from the other bypass groups.ConclusionsXenon appears to have no effect on the inflammatory response to cardiopulmonary bypass, making its previously described neuroprotective effect during cardiopulmonary bypass likely independent of any inflammation modulation.

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