• Journal of anesthesia · Jan 2005

    Clinical Trial

    Plasma concentration for optimal sedation and total body clearance of propofol in patients after esophagectomy.

    • Daisuke Takizawa, Eri Sato, Koichi Nishikawa, Hiroshi Hinohara, Haruhiko Hiraoka, Shigeru Saito, Fumio Goto, and Fumio Kunimoto.
    • Intensive Care Unit, Gunma University Hospital, Maebashi, Japan.
    • J Anesth. 2005 Jan 1;19(1):88-90.

    AbstractThe present study investigated plasma propofol concentration for optimal sedation and total body clearance in patients who required sedation for mechanical ventilation after esophagectomy. Seven patients after esophagectomy were enrolled in this study. Plasma propofol concentrations were measured with high performance liquid chromatography. Total body clearance was calculated from the steady-state concentration. The infusion rate of propofol for achieving the sedation score of level 3 (drowsy, responds to verbal stimulation) was 1.74 +/- 0.82 mg kg(-1) h(-1) (mean +/- SD, n = 7) when the plasma propofol concentration and the total body clearance were 0.85 +/- 0.24 microg ml(-1) and 1.83 +/- 0.54 l min(-1) (mean +/- SD, n =7), respectively.

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