• A Schultz, B Schultz, U Grouven, F A Beger, and G Korsch.
• Medizinische Hochschule Hannover, Abt. Anaesthesie IV, Klinikum Hannover-Oststadt, Podbielskistrasse 380, D-30659 Hannover, Germany.
• Pharm World Sci. 2001 Apr 1;23(2):82-5.

ObjectiveIn this article unexpected EEG findings are described which were observed during EEG monitoring under sevoflurane anesthesia.MethodIn seven non-epileptic adult patients sevoflurane was administered as inhalation anesthetic during routinely performed surgical operations. The EEG was recorded continuously as part of the standard monitoring process and served mainly as a dosage guide for anesthetics/narcotics.Main Outcome MeasureOccurrence of sharp transients in the EEG resembling distinctive waves which can be seen in epileptic disorders.ResultsIn six of the seven patients under 8.0% sevoflurane, sharp transients were observed which appeared in very deep EEG stages, mostly with endtidal sevoflurane concentrations of 4.8-5.9%. The findings are in accordance with observations in non-epileptic children from our clinic.ConclusionsThe clinical significance of the observed EEG pattern under sevoflurane anesthesia is still unclear. Taking into consideration that convulsive and nonconvulsive status epilepticus can be followed by signs of brain damage, it would appear to be important to further investigate the phenomenon.

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