• Bastien Joubert, Philippe Kerschen, Anastasia Zekeridou, Virginie Desestret, Véronique Rogemond, Marie-Océane Chaffois, François Ducray, Vincent Larrue, Benoit Daubail, Ahmed Idbaih, Dimitri Psimaras, Jean-Christophe Antoine, Jean-Yves Delattre, and Jérôme Honnorat.
• Université Claude Bernard Lyon 1, Lyon, France2Institut National de la Santé et de la Recherche Médicale (INSERM) et Centre National de la Recherche Scientifique (CNRS), Equipe Neuro-oncologie et Neuro-inflammation, Centre de Recherche en Neurosciences de.
• JAMA Neurol. 2015 Oct 1;72(10):1163-9.

ImportanceThe clinical features of autoimmune encephalitis associated with antibodies against the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR-Abs) remain poorly defined.ObjectivesTo describe 7 patients with encephalitis and AMPAR-Abs and to provide a review of the literature on this disease entity.Design, Setting, And ParticipantsThe setting was the Centre National de Référence pour les Syndromes Neurologiques Paranéoplasiques (Lyon, France), and participants were 7 consecutive patients diagnosed as having encephalitis and AMPAR-Abs between January 1, 2010, and December 1, 2014. Patients' clinical data were analyzed, with a median follow-up period of 12 months (range, 2-31 months). Relevant articles were identified in the MEDLINE database using the keywords autoimmune encephalitis and AMPA receptor antibodies until February 15, 2015.Main Outcomes And MeasuresModes of onset, full clinical presentations, and cancer prevalence.ResultsThe patients included 4 women and 3 men (median age, 56 years). Four main modes of encephalitis onset were observed, including confusion (3 patients), epileptic (1 patient), amnestic (1 patient), and a severe form of fulminant encephalitis (2 patients). In contrast with previous reports, we observed only 1 patient with seizures. Two patients had cancer (1 lung carcinoma and the other thymic carcinoma). Analysis of the literature identified 35 published cases of encephalitis and AMPAR-Abs, including 18 with clinical data. The same modes of encephalitis onset were observed, including confusion (12 patients), epileptic (1 patient), amnestic (3 patients), and fulminant encephalitis (2 patients). Eleven patients were initially seen with a neoplasm (lung, breast, thymoma, or ovary).Conclusions And RelevanceThe clinical spectrum of AMPAR encephalitis is variable. Cancer was found in 13 of 27 patients (48%) with known cancer status. Most patients are seen with symptoms suggestive of autoimmune limbic encephalitis, although they can be paucisymptomatic or may manifest severe panencephalitis that evolves to a minimally conscious state and diffuse cortical atrophy. Patients suspected of having autoimmune encephalitis should undergo screening for serum and cerebrospinal fluid AMPAR-Abs.

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