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Editorial Comment
Detrimental role of humoral signalling in cardio-renal cross-talk.
- Vincenzo Cantaluppi, Sergio Dellepiane, Alessandro D Quercia, and Silvia Ferrario.
- Crit Care. 2014 Jan 1; 18 (1): 404.
AbstractIn critically ill patients, any acute organ injury is associated with a sudden change of circulating factors that may play a role in distant organ dysfunction through a complex cross-talk. In this issue, Virzì and colleagues discuss the relevance of humoral signalling between heart and kidney, focusing on type 1 and type 3 cardio-renal syndrome. We herein review the mechanisms of heart-kidney cross-talk, discussing the role of circulating detrimental mediators in the pathogenetic mechanisms of cardio-renal syndrome.
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