• Daisuke Mikami, Harumasa Nakazawa, Kiyoshi Moriyama, and Tomoko Yorozu.
• Department of Anesthesiology, Kyorin University School of Medicine, Tokyo 181-8611.
• Masui. 2014 Feb 1;63(2):138-42.

BackgroundWe hypothesized that pre-operative BNP levels predict postoperative morbidity and mortality in patients undergoing non-emergent cardiac surgery.MethodsWe retrospectively assessed patients who underwent non-emergent cardiac surgery at our institution regarding major morbidity (prolonged ventilation > 48 hours and prolonged ICU stay > 7 days), and all-cause mortality within 30 days. The cutoff value of BNP for prolonged ventilation was also evaluated.ResultsA total of 62 patients with a mean age of 68.7 +/- 12.4 and preoperative BNP value of 391+/- 324 pg x ml(-1) were included. Risk factors for prolonged ventilation were high preoperative BNP and combined procedures. The risk factor for prolonged ICU stay was high preoperative BNP alone. All-cause mortality within 30 days were associated with high preoperative BNP and low intraoperative urine output. A preoperative BNP value (> 259 pg x ml(-1)) provided the optimal BNP cutoff point for prolonged ventilation, and predicted postoperative hemodynamic instability.ConclusionsPreoperative BNP predicted postoperative morbidity and mortality.

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