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- Alessandra Pesenti, Alberto Priori, Marco Locatelli, Marcello Egidi, Paolo Rampini, Filippo Tamma, Elena Caputo, Valentina Chiesa, and Sergio Barbieri.
- Dipartimento di Neuroscienze e Organi di Senso, IRCCS-Ospedale Maggiore Milano, Milano, Italy.
- Mov. Disord. 2003 Nov 1;18(11):1341-5.
AbstractDeep brain stimulation (DBS) of subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. It also provides an opportunity to record neural activity from the human basal ganglia. In this study, to investigate the involvement of the human STN in sensory functions, we recorded somatosensory evoked potentials (SEPs) elicited by contralateral median-nerve stimulation, from STN electrodes implanted for DBS in patients with Parkinson's disease. We suggest that the STN N18 component of SEPs in Parkinson's disease is a mainly local field potential elicited by muscle afferent input to the nucleus.
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