• Am. J. Med. Sci. · Nov 2001

    Historical Article

    History of medical ethics and perspectives on disparities in minority recruitment and involvement in health research.

    • B Seto.
    • Office of Reports and Analysis, National Institutes of Health, Office of Extramural Research, Bethesda, Maryland 20892-0164, USA. bs11e@nih.gov
    • Am. J. Med. Sci. 2001 Nov 1;322(5):248-52.

    AbstractThe legitimate and successful recruitment of minorities as research participants in clinical trials should be addressed from an ethical and historical perspective. To gain an appreciation of the challenges, to develop strategies and to overcome the disparities of minority involvement in clinic trials, it is essential to be cognizant of previous violations and abuses of ethics and human rights. Also significant are major legislation, regulations and federal initiatives that resulted from those abuses. From history, we have learned we cannot generalize data and assume that, if we have the majority group in clinical trials, then we can accurately apply that data to minorities. There are cultural and environmental differences; thus, it is absolutely crucial that researchers approach recruitment of minority groups with cultural competence and cultural sensitivity. Federal regulations and legislation set the framework for protection of human participants in research.

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