• Neurology · Jun 2006

    Randomized Controlled Trial Multicenter Study

    Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.

    • R B Postuma, A J Espay, C Zadikoff, O Suchowersky, W R W Martin, A-L Lafontaine, R Ranawaya, R Camicioli, and A E Lang.
    • Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada. ron.postuma@muhc.mcgill.ca
    • Neurology. 2006 Jun 27;66(12):1941-3.

    AbstractElevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.

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