• John G Augoustides, Alberto Pochettino, E Andrew Ochroch, Doreen Cowie, Michael L McGarvey, Justin Weiner, Andrew J Gambone, Dawn Pinchasik, Albert T Cheung, and Joseph E Bavaria.
• Department of Anesthesia, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA. yiandoc@hotmail.com
• J. Cardiothorac. Vasc. Anesth. 2006 Feb 1;20(1):8-13.

ObjectiveThe purpose of this study was to describe clinical predictors for prolonged length of stay in the intensive care unit (PLOS-ICU) after adult thoracic aortic surgery requiring standardized deep hypothermic circulatory arrest (DHCA); and to determine the incidence of PLOS-ICU after DHCA, univariate predictors for PLOS-ICU, and multivariate predictors for PLOS-ICU.Study DesignA retrospective and observational study. PLOS-ICU was defined as longer than 5 days in the ICU.Study SettingCardiothoracic operating rooms and the ICU.ParticipantsAll adults requiring thoracic aortic repair with DHCA INTERVENTIONS: None.Main ResultsThe cohort size was 144. The incidence of PLOS-ICU was 27.8%. The mortality rate was 11.1%. Univariate predictors for PLOS-ICU were age, stroke, DHCA duration, vasopressor dependence >72 hours, mediastinal re-exploration for bleeding, and renal dysfunction. Multivariate predictors for PLOS-ICU were stroke, vasopressor dependence >72 hours, and renal dysfunction.ConclusionsPLOS-ICU after DHCA is common. The identified multivariate predictors merit further hypothesis-driven research to enhance perioperative protection of the brain, kidney, and cardiovascular system.

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