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- J J Chen, K C Hung, K Lu, S W Yu, C C Chang, J Spielberger, P Y Ku, and P H Tan.
- Department of Anaesthesia, Kaohsiung Armed Forces Hospital, Kaohsiung, Taiwan.
- Anaesthesia. 2012 Nov 1;67(11):1225-31.
AbstractWe examined the pre-emptive analgesic effect of a cyclooxygenase (COX)-2 inhibitor in a rat surgical pain model and characterised the changes in cutaneous COX-2 around a surgical site. Thermal hyperalgesia and mechanical allodynia were tested in the rats for three days after incision and skin tissues were collected for analysis of COX-2. There was decreased expression of cutaneous COX-2 one day after surgical incision. Pre-incision injection of the COX-2 inhibitor significantly inhibited expression of COX-2 and also reduced thermal hyperalgesia (but not mechanical allodynia) compared with the post-incision COX-2-inhibitor injection group, one day after incision.Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.
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