• Ann. Clin. Biochem. · Mar 2002

    Biochemical markers of neonatal sepsis: value of procalcitonin in the emergency setting.

    • Jean Guibourdenche, Antoine Bedu, Loïc Petzold, Martine Marchand, Patricia Mariani-Kurdjian, Marie-Françoise Hurtaud-Roux, Yannick Aujard, and Dominique Porquet.
    • Department of Biochemistry Hôpital Robert Debré Paris, France. jean.guibourdenche@rdb.ap-hop-paris.fr
    • Ann. Clin. Biochem. 2002 Mar 1;39(Pt 2):130-5.

    BackgroundWe evaluated procalcitonin (PCT) assay in the emergency diagnosis of neonatal bacterial infection, especially in preterm infants, relative to C-reactive protein (CRP) and fibrinogen.MethodsOne hundred and twenty neonates (32 preterm), of whom 21 were infected, were tested.ResultsConcentrations of PCT, CRP and fibrinogen in uninfected infants were not affected by gestational age at birth. Concentrations of CRP and PCT increased rapidly during the first 24 h of life, while fibrinogen concentrations increased gradually from birth. All marker concentrations were significantly greater in neonates with bacterial infection. Receiver-operating characterstic analysis showed that optimum cut-off values for fibrinogen, CRP and PCT were 3.0 g/L, 7.5 mg/L and 2.5 microg/L respectively, for the diagnosis of sepsis at birth.ConclusionsDetermination of PCT is of value in excluding bacterial infection in neonates since it has a negative predictive value of 93%.

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