• Fundam Clin Pharmacol · Oct 2008

    Review

    Altered pharmacology in the Intensive Care Unit patient.

    • Giovanni Zagli, Francesca Tarantini, Manuela Bonizzoli, Alessandro Di Filippo, Adriano Peris, Angelo Raffaele De Gaudio, and Pierangelo Geppetti.
    • Department of Critical Care Medicine and Surgery, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. giovanni.zagli@unifi.it
    • Fundam Clin Pharmacol. 2008 Oct 1;22(5):493-501.

    AbstractCritically ill patients, not infrequently present alterations of physiological parameters that determine the success/failure of therapeutic interventions as well as the final outcome. Sepsis and polytrauma are two of the most common and complex syndromes occurring in Intensive Care Unit (ICU) and affect drug absorption, disposition, metabolism and elimination. Pharmacological management of ICU patients requires consideration of the unique pharmacokinetics associated with these clinical conditions and the likely occurrence of drug interaction. Rational adjustment in drug choice and dosing contributes to the appropriateness of treatment of those patients.

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