• Neuroscience letters · Sep 2004

    Comparative Study

    Gabapentin relieves mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.

    • Seung Keun Back, Sang Youn Won, Seung Kil Hong, and Heung Sik Na.
    • Department of Physiology, Medical Science Research Center, Korea University College of Medicine, 126-1 Anam-dong 5 Ga, Sungbuk-Gu, Seoul 136-705, Korea.
    • Neurosci. Lett. 2004 Sep 30;368(3):341-4.

    AbstractAlthough recent studies demonstrated the relieving effect of gabapentin on neuropathic pain, the effect has not been sufficiently examined. In the present study, we investigated the effect of gabapentin on mechanical, warm and cold allodynia in a rat model of peripheral neuropathy. Under enflurane anesthesia, animals were subjected to the partial injury of the nerves innervating the tail. Behavioral tests for mechanical, cold and warm allodynia on the tail were performed by von Frey hair (2.0 g) stimulation, 4 and 40 degrees C water immersion, respectively. Intraperitoneal injection of gabapentin (30, 100, 300 mg/kg) significantly alleviated mechanical, warm and cold allodynia in a dose-dependent manner. Our results suggest that gabapentin is an effective agent against mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.

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