• Ther Apher Dial · Jun 2012

    Plasma separation by centrifugation and subsequent plasma filtration: impact on survival in a pig model of sepsis.

    • Martin Sauer, Jens Altrichter, Thomas Mencke, Sven Klöhr, Maren Thomsen, Hans J Kreutzer, Gabriele Nöldge-Schomburg, and Steffen R Mitzner.
    • Department of Anesthesiology and Intensive Care Medicine, Medical Faculty of the University of Rostock, Rostock, Germany. martin.sauer@uni-rostock.de
    • Ther Apher Dial. 2012 Jun 1;16(3):205-12.

    AbstractThe impact on survival of a combination of plasma separation by centrifugation and subsequent plasma filtration was tested in a bacterial sepsis model in pigs. In this animal study 19 pigs were included. Groups II and III received an intravenous lethal dose of live Staphylococcus aureus over 1 h; group I received saline (non-septic control--NC). Groups I and II were treated by an extracorporeal circuit consisting of online centrifugation and subsequent plasma filtration (group II: treated group--TG) for 4 h; group III had no specific treatment (septic control, SC). The observation time was 7 days. All animals of group I (NC) and group II (TG) survived, while all animals of group III (SC) died during the observation time. Extracorporeal therapy with online centrifugation and plasma filtration significantly improved survival in a pig model of sepsis. Further studies with this approach are encouraged.© 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis.

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