• Brain Stimul · Mar 2014

    Case Reports

    Eight-years failure of subthalamic stimulation rescued by globus pallidus implant.

    • Brigida Minafra, Alfonso Fasano, Nicolò Gabriele Pozzi, Roberta Zangaglia, Domenico Servello, and Claudio Pacchetti.
    • Parkinson's Disease and Movement Disorders Unit, National Institute of Neurology Foundation "C. Mondino", Pavia, Italy; Interdepartmental Research Center for Neurodegenerative Disease, National Institute of Neurology Foundation "C. Mondino", Pavia, Italy. Electronic address: bri_mi@hotmail.it.
    • Brain Stimul. 2014 Mar 1;7(2):179-81.

    BackgroundDeep brain stimulation is the surgical procedure of choice in patients with Parkinson's disease. The subthalamic nucleus and the globus pallidus interna are the two most common targets used to treat Parkinson's disease.MethodsWe describe three patients with previous effective subthalamic deep brain stimulation in whom globus pallidus interna deep brain stimulation was performed as "rescue" surgery, 8 years after the original operation.ResultsTwo years after globus pallidus surgery the reduction of dystonia and dyskinesias led to an improvement of motor symptoms. In two patients, painful dystonias disappeared and motor fluctuations markedly improved. One patient achieved an improvement in freezing.ConclusionAfter 24 months of follow up, our observations suggest that globus pallidus deep brain stimulation, can improve motor fluctuations, dyskinesia and axial symptoms.Copyright © 2014 Elsevier Inc. All rights reserved.

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