• Parkinsonism Relat. Disord. · Nov 2010

    Predictive factors affecting early deterioration of axial symptoms after subthalamic nucleus stimulation in Parkinson's disease.

    • Atsushi Umemura, Yuichi Oka, Kenji Okita, Takanari Toyoda, Noriyuki Matsukawa, and Kazuo Yamada.
    • Department of Neurosurgery, Nagoya City University Graduate School of Medicine, Mizuho-ku, Nagoya 467-8601, Japan. aume@med.nagoya-cu.ac.jp
    • Parkinsonism Relat. Disord. 2010 Nov 1;16(9):582-4.

    AbstractSubthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment option for medically refractory Parkinson's disease (PD). However, some patients show deterioration of axial symptoms within a short time after surgery. We studied 43 patients who underwent bilateral STN-DBS and investigated predictive factors affecting early deterioration of axial symptoms. Among 43 patients, 16 patients showed obvious deterioration of axial symptoms within three years of surgery. Multiple logistic regression analysis indicated that the significant independent variables related to early deterioration of axial symptoms were rapidly progressive short duration of the disease and advanced age at surgery. These results suggest that patients with rapidly progressing PD, who need early surgical intervention, tend to show early deterioration of axial symptoms after STN-DBS.Copyright © 2010 Elsevier Ltd. All rights reserved.

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