• Joseph S Cheng, Paul M Arnold, Paul A Anderson, Dena Fischer, and Joseph R Dettori.
• Department of Neurosurgery, Vanderbilt University Medical Center, T-4224 Medical Center North, Nashville, TN 37232, USA. joseph.cheng@vanderbilt.edu
• Spine. 2010 Apr 20;35(9 Suppl):S117-24.

Study DesignSystematic review.ObjectiveTo determine the high-risk populations for thromboembolic events in spine surgery patients, the risk of anticoagulation in spine surgery patients by type of anticoagulation, and whether there is a safe perioperative window of nonanticoagulation for these high-risk patients.Summary Of Background DataThromboembolic complications after major spinal surgery is a significant risk for patients. Anticoagulation to reduce this risk is of concern because of the possibility of excessive bleeding or postoperative hematomas and associated neurologic deficits. There seems to be a paucity of literature on this topic.MethodsA systematic review of the English-language literature was undertaken for articles published between January 1990 and December 2008. Electronic databases and reference lists of key articles were searched to identify published studies examining coagulopathy in major spine surgery. Two independent reviewers assessed the strength of literature using the Grading of Recommendations Assessment, Development, and Evaluation criteria, assessing quality, quantity, and consistency of results. Disagreements were resolved by consensus.ResultsA total of 93 articles were initially screened, and 29 ultimately met the predetermined inclusion criteria. The risk of thromboembolism in patients not receiving chemical prophylaxis was slightly higher in surgery to correct deformity (5.3%) and trauma patients (6.0%) than in surgery for degenerative conditions (2.3%). Fatal pulmonary embolism was rare. Bleeding complications occurred rarely with the use of anticoagulation; risk of major bleeding ranged from 0.0% to 4.3% across several types of anticoagulants. Postoperative hematoma was reported in only 10 of 2507 patients.ConclusionVenous thromboembolism is uncommon after elective spine surgery. Trauma patients are at increased risk, and chemical prophylaxis should be considered. The safe timing of the administration of anticoagulation agents is unknown.

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