• Véronique Pottier, Cédric Daubin, Nicolas Lerolle, Cathy Gaillard, Gérald Viquesnel, Benoit Plaud, Jean-Luc Hanouz, and Pierre Charbonneau.
• Department of Anesthesia and Surgical Intensive Care, Caen University Hospital, France. pottier-v@chu-caen.fr
• Am J Infect Control. 2012 Apr 1;40(3):241-6.

BackgroundThis study was conducted to determine the frequency, predictors, and clinical impact of adverse events (AEs) related to invasive procedures in the intensive care unit (ICU).MethodsThis was a prospective observational study of ICUs in a university hospital.ResultsA total of 893 patients requiring invasive procedures were admitted over a 1-year period. Among these, 310 patients (34.7%) experienced a total of 505 AEs. The mean number of AEs per patient was 1.6 ± 1.1 (range, 1-7). Infectious AEs were significantly more frequent than mechanical AEs (60.4% vs 39.6%; P = .01). Factors independently associated with AE occurrence were isolation of multidrug-resistant bacteria at ICU admission, >5 invasive procedures, and ICU length of stay >8 days. Thirty-three AEs (6.5%) resulted in severe clinical impact, including 24 deaths. Ventilator-associated pneumonia (VAP) accounted for 62.5% of the deaths related to AEs.ConclusionsOne-third of critically ill patients experienced AEs related to invasive procedures. Severe AEs were associated with 11% of all ICU deaths. VAP was the most frequent AE related to death. An improved assessment of the risk-benefit balance before each invasive procedure and increased efforts to decrease VAP prevalence are needed to reduce AE-related mortality.Copyright © 2012 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

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