• Rev Assoc Med Bras · Jan 1998

    Case Reports

    [Toxic epidermal necrolysis after the use of intermediate dose of cytosine arabinoside].

    • M S Figueiredo, M Yamamoto, and J Kerbauy.
    • Departamento de Medicina, Universidade Federal de São Paulo-Escola Paulista de Medicina.
    • Rev Assoc Med Bras. 1998 Jan 1;44(1):53-5.

    UnlabelledToxic epidermal necrolysis is a drug-induced dermatologic disease related to Lyell syndrome, erythema multiforme and Stevens-Johnson syndrome.PurposeTo report a fatal case of toxic epidermal necrolysis owing to intermediate dose of cytarabine.Case ReportA 16 year-old female patient with acute lymphocytic leukemia (LLA-L1) treated with the Protocol of the Brazilian Group for Treatment of Leukemia of Childwood (GBTLI-85-AR). On the second day after the administration of intermediate dose of cytarabine (1.5 g/m2 i.v. every 12 hours for 3 days), she presented bullous lesions in the left buttock that disseminated envolving to necrosis, sepsis, and death on the 13th day.ConclusionCytarabine is frequently associated with dermatologic toxicity but, until now, there is no other case of toxic epidermal necrolysis described.

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