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Anaesth Intensive Care · Oct 1997
Case ReportsTricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine.
- D J Sandeman, T I Alahakoon, and S C Bentley.
- Department of Anaesthesia, Wollongong Hospital, N.S.W.
- Anaesth Intensive Care. 1997 Oct 1;25(5):542-5.
AbstractSerious complications from tricyclic antidepressant (TCA) overdose are uncommon. We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse. A total of 400 mmol of sodium bicarbonate, 5 mg of adrenaline and 80 mg of sotalol were given during 50 minutes of cardiac arrest. The patient made a full recovery with no apparent neurological sequelae. The highest TCA plasma level we could find in the published literature was 4873 ng/ml4; our patient's peak TCA level was 6000 ng/ml. Tricyclic antidepressant overdose is a common cause of intensive care unit admission. It has a low mortality rate.
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