• Acta Anaesthesiol Scand · Jul 1985

    Comparative Study

    Etomidate infusion and adrenocortical function. A study in elective surgery.

    • M Wanscher, E Tønnesen, M Hüttel, and K Larsen.
    • Acta Anaesthesiol Scand. 1985 Jul 1;29(5):483-5.

    AbstractThe adrenocortical response to a short tetracosactrin (Synacthen) test was studied in 11 patients receiving either etomidate infusion or thiopentone infusion used to maintain anaesthesia for abdominal hysterectomy. Pethidine was used as the narcotic component. The results showed that etomidate infusion (median 28.5 ug/kg/min) completely blocked the adrenocortical response to corticotropin stimulation for at least 24 h after surgery. No suppression was found in patients receiving thiopentone infusion. It is concluded that etomidate cannot be recommended for routine induction and maintenance of anaesthesia.

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