• Corinna Binder-Heschl, Berndt Urlesberger, Martin Koestenberger, Bernhard Schwaberger, Georg M Schmölzer, and Gerhard Pichler.
• Research Unit for Cerebral Development and Oximetry, Medical University of Graz, Graz, Austria; Research Unit for Neonatal Micro- and Macrocirculation, Medical University of Graz, Graz, Austria; Division of Neonatology, Department of Pediatrics, Medical University, Graz, Austria.
• Acta Paediatr. 2015 Jan 1;104(1):32-7.

AimThis prospective observational study investigated if N-terminal probrain natriuretic peptide (NT-proBNP), a cardiac biomarker, correlated with cerebral tissue oxygen saturation (crSO2) in preterm infants on their first day of life.MethodsUsing near infrared spectroscopy (NIRS), crSO2 was measured on the right forehead of preterm infants for 24 h. We also recorded arterial oxygen saturation (SpO2 ) and calculated fractional tissue oxygen extraction (cFTOE) values. At the end of the NIRS measurement, blood was taken to analyse NT-proBNP. Mean values for the 24-h period were calculated for crSO2 , cFTOE, SpO2 and these values were correlated to NT-proBNP. An echocardiography was performed in all infants during the measurement period.ResultsWe analysed 35 preterm neonates (33 ± 2 weeks, 1965 ± 523 g). NIRS measurements started at 3 ± 1 h and blood samples were taken at 24 ± 5 h postnatal. Echocardiography showed an open ductus arteriosus in all infants. Mean NT-proBNP was 4978 ± 3566 pg/mL, crSO2 was 76 ± 8%, and cFTOE was 0.20 ± 0.08. NT-proBNP correlated negatively with crSO2 (r = -0.75; p ≤ 0.001) and positively with cFTOE (r = 0.731; p ≤ 0.001).ConclusionThese results emphasise that crSO2 is influenced by cardiac function, in addition to oxygen consumption, arterial oxygen saturation and vascular resistance, and this can be measured by NT-proBNP.©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

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