• Can J Anaesth · Apr 2014

    Randomized Controlled Trial Comparative Study

    The addition of epidural local anesthetic to systemic multimodal analgesia following lumbar spinal fusion: a randomized controlled trial.

    This small study of patients having lumbar spinal fusion was unable to show a statistically significant reduction in postoperative opioid consumption in those receiving epidural bupivacaine/opioid versus those receiving a sham epidural.

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    • Stephen Choi, Y Raja Rampersaud, Vincent W S Chan, Oma Persaud, Arkadiy Koshkin, Paul Tumber, and Richard Brull.
    • Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
    • Can J Anaesth. 2014 Apr 1;61(4):330-9.

    PurposeThis randomized trial aimed to evaluate the effects of adding continuous epidural analgesia with a bupivacaine and hydromorphone solution to systemic multimodal analgesia following one- or two-level lumbar spinal fusion.MethodsThirty-nine patients undergoing lumbar spinal fusion, stratified for sex and one- or two-level fusion, were randomized to receive a continuous postoperative epidural infusion of either 0.1% bupivacaine with 15 μg·mL(-1) hydromorphone (LA group) or 0.9% saline (NS group) at 6 mL·hr(-1) for 48 hr through an epidural catheter placed intraoperatively. All patients received a standardized postoperative multimodal analgesia regimen. Patients, healthcare providers, and research staff were blinded. The primary outcome measure was cumulative opioid consumption (oral morphine equivalent) during the first 48 hr postoperatively.ResultsThe mean (SD) cumulative opioid consumption 48 hours postoperatively was 249.3 (143.3) mg in the NS group and 184.7 (208.1) mg in the LA group (mean difference 64.6 mg; 95% confidence interval -54.3 to 183.5; P = 0.27). There were no adverse events in either group.ConclusionContinuous epidural infusion combined with systemic multimodal analgesia resulted in a mean reduction in 48-hr cumulative opioid consumption of 64.6 mg (95% confidence interval -54.3 to 183.5) following one- or two-level lumbar spinal fusion. This estimate of effect is imprecise, and the routine use of continuous epidural analgesia in this surgical population is not yet warranted. This trial was registered at www.clinicaltrials.gov : NCT00644111.

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    This small study of patients having lumbar spinal fusion was unable to show a statistically significant reduction in postoperative opioid consumption in those receiving epidural bupivacaine/opioid versus those receiving a sham epidural.

    Daniel Jolley  Daniel Jolley
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    1

    In the publicly available version no mention of risks. Locally this technique was popular a while ago but abandonded after a few total spinals and such

    Allan Palmer  Allan Palmer
     
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