• J. Child Neurol. · Mar 2004

    Case Reports

    Subacute sclerosing panencephalitis with fulminating course: follow-up magnetic resonance spectroscopy (MRS) findings.

    • Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Mehmet Aslan, Kaya Sarac, and Cengiz Yakinci.
    • Department of Radiology, Inonu University School of Medicine, Turgut Ozal Medical Center, Malatya, Turkey. aalkan@inonu.edu.tr
    • J. Child Neurol. 2004 Mar 1;19(3):233-8.

    AbstractThe fulminating form of subacute sclerosing panencephalitis is an extremely rare condition. Imaging findings are usually not correlated with clinical staging. We describe a 4-year-old girl with severe neuronal loss, demyelination, and gliosis in subcortical white matter by magnetic resonance spectroscopic examination even though she was diagnosed as clinical stage II. In 2 months' time, her clinical status worsened significantly. Follow-up magnetic resonance spectroscopy revealed findings that were consistent with clinical status. It is our opinion that magnetic resonance spectroscopy could demonstrate a rapidly progressive fulminating course of subacute sclerosing panencephalitis even in the early clinical stages.

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