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Randomized Controlled Trial Clinical Trial
The cardiovascular responses to double lumen endobronchial intubation and the effect of esmolol.
- J P Thompson, K J West, and A J Hill.
- Glenfield General Hospital NHS Trust, Leicester, UK.
- Anaesthesia. 1997 Aug 1;52(8):790-4.
AbstractThe cardiovascular responses to double lumen endobronchial intubation and the effect of esmolol were examined in two groups of 10 ASA 2 & 3 patients undergoing pulmonary surgery in a double blind, placebo-controlled study. Endobronchial intubation was associated with a significant increase in arterial pressure and heart rate (p = 0.004), and a significant increase in plasma noradrenaline concentrations (p < 0.01) in the control group. The haemodynamic changes were smaller (p < 0.001) in the patients who received esmolol compared with the changes in the the control group. The increase in plasma noradrenaline concentrations was significantly greater (p < 0.05) in the esmolol group. The pressor response to endobronchial intubation in this study was of a similar magnitude to that known to occur in response to tracheal intubation.
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