• Ayse Mizrak, Maruf Sanli, Semsettin Bozgeyik, Rauf Gul, Suleyman Ganidagli, Elif Baysal, and Unsal Oner.
• Anesthesiology and Reanimation, Gaziantep University School of Medicine Gaziantep/Turkey. aysemizrak@mynet.com
• Middle East J Anaesthesiol. 2012 Feb 1;21(4):605-12.

BackgroundThe purpose of this study is to investigate the suitability of dexmedetomidine as a helpful sedative agent in direct laryngoscopic biopsy (DLB), under total intravenous anesthesia (TIVA).MethodsIn this double blind randomised study, patients were allocated to receive dexmedetomidine 0.5 microg/kg (group D, n = 20) or saline placebo (group P, n = 20) intravenously. Forty ASA I-III patients were infused propofol and administered rocuronium bromur. They were intubated and performed biopsy. Aldrete scores, intraoperative propofol and postoperative analgesic requirements, satisfaction scores, recovery time, Ramsay sedation scale (RSS), haemodynamic changes and side effects were recorded.ResultsPostoperative analgesic requirement in group D was significantly lower and satisfaction scores and RSS were significantly higher than in group P. Additionally, MAP (mean arterial blood pressure) significantly decreased at post-extubation time in group D.ConclusionThe premedication with a single dose of dexmedetomidine decreases intraoperative propofol and postoperative analgesic requirements, increases the postoperative satisfaction and RSS considerably in patients undergoing DLB under TIVA.

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