• Lancet · Feb 2001

    Letter Case Reports

    Impaired fatty acid oxidation in propofol infusion syndrome.

    • A Wolf, P Weir, P Segar, J Stone, and J Shield.
    • Lancet. 2001 Feb 24;357(9256):606-7.

    AbstractPropofol infusion syndrome is a rare but frequently fatal complication in critically ill children given long-term propofol infusions. We describe a child who developed all the clinical features of propofol infusion syndrome and was treated successfully with haemofiltration. Biochemical analysis before haemofiltration showed a large rise in plasma concentrations of malonylcarnitine (3.3 micromol/L) and C5-acylcarnitine (8.4 micromol/L), which returned to normal after recovery. Abnormalities are consistent with specific disruption of fatty-acid oxidation caused by impaired entry of long-chain acylcarnitine esters into the mitochondria and failure of the mitochondrial respiratory chain at complex 11.

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