• Rheumatol. Int. · Jun 2007

    Review Case Reports

    Beneficial effect of treatment with cyclosporin A in a case of refractory antisynthetase syndrome.

    • Magdalena Jankowska, Barbara Butto, Alicja Debska-Slizień, and Bolesław Rutkowski.
    • Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Ul. Debinki 7, 80-294 Gdansk, Poland. maja@amg.gda.pl
    • Rheumatol. Int. 2007 Jun 1;27(8):775-80.

    AbstractWe report a case of idiopathic inflammatory myopathy accompanied with the presence of anti-Jo1 antibodies and complicated by diffuse parenchymal lung disease (antisynthetase syndrome). Efficacy of different therapeutic agents, including corticosteroids, cyclophosphamide and cyclosporin A, is described. We present beneficial effect of cyclosporin A and corticosteroids regimen, and confirm no benefits of plasmapheresis. An interesting association of the disease onset with toxoplasmosis infection is discussed and difficulties regarding diagnosis of cardiac involvement are addressed. We also review other case reports of this rare disorder of poor prognosis.

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