• Yonathan Freund, Patricia Jabre, Jerome Mourad, Frederic Lapostolle, Paul-Georges Reuter, Maguy Woimant, Nicolas Javaud, and Frederic Adnet.
• Emergency Department, Hôpital Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France; Université Pierre et Marie Curie Paris 6 (Sorbonne Université), Paris, France. Electronic address: yonathanfreund@gmail.com.
• J Crit Care. 2014 Jun 1;29(3):386-9.

PurposeRelative adrenal insufficiency (RAI) has been reported as a predictor of mortality in septic patient; however, its effects on mortality and outcomes for critically ill patients remain debatable. The objective of this study was to assess the effect of RAI on prognostic outcomes in patients after out-of-hospital rapid sequence intubation (RSI) and factors associated with the onset of RAI.Patients And MethodsA prespecified ancillary study of KETASED, a randomized prospective multicenter trial, was conducted. Three hundred ten patients who underwent RSI in an out-of-hospital setting had baseline cortisol and adrenocorticotropic hormone response test measurements within 24 hours of intensive care unit admission and were included.ResultsThe mean (SD) age was 55 (19) years, with a mean (SD) Sequential Organ Failure Assessment score of 9 (4). Two hundred forty-seven (69%) patients presented with RAI. Baseline characteristics were similar between patients with and without RAI, except for the use of etomidate as a sedative agent (63% of patients with RAI vs 21%, P<.001), and history of chronic kidney disease. There was no difference in terms of 28-day mortality between the 2 groups (21% vs 19%, P=.65) and in terms of other 28-day prognosis end points.ConclusionIn critically ill patients who require RSI, RAI is common and is not associated with worsened outcomes in our cohort.Copyright © 2014 Elsevier Inc. All rights reserved.

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